aldosterone receptors การใช้

• Aldosterone receptors are present on the epithelial cells of the distal nephron in the kidney.
• These mineralocorticoids cross-react with the aldosterone receptor, activating it and raising blood pressure.
• Blockade of the aldosterone receptor with spironolactone removed the ventricular arrhythmia predisposition in " Kcne3 "-/-mice.
• Aldosterone receptor antagonists are not recommended as first-line agents for blood pressure, but spironolactone and eplerenone are both used in the treatment of heart failure and resistant hypertension.
• The mineralocorticoid receptor is stimulated by both aldosterone and cortisol, but a mechanism protects the body from excess aldosterone receptor stimulation by glucocorticoids ( such as cortisol ), which happen to be present at much higher concentrations than mineralocorticoids in the healthy individual.